Gastrointestinal Stromal Tumors

Some of the drugs in the pipeline for colorectal cancer therapeutics are Lonsurf, CYRAMZA (ramucirumab), TS-1/Teysuno, CPP-1X (eflornithine hydrochloride), MelCancerVac, Xilonix, and Nintedanib. There are various medications such as chemotherapy drugs, immunotherapy, and leucovorin (chemoprotectant) that can be used to treat colorectal cancer. Chemotherapy drugs for the treatment of colorectal cancer include anti-metabolites such as fluorouracil and capecitabine. Monoclonal antibodies used in immunotherapy as part of the treatment of colorectal cancer are bevacizumab, cetuximab, and panitumumab. Bevacizumab (Avastin®), ramucirumab (Cyramza®), and ziv-aflibercept (Zaltrap®) are drugs used for colon cancer that target vascular endothelial growth factor (VEGF). VEGF is a protein that helps tumors form new blood vessels to get nutrients (a process known as angiogenesis).

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