Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series : World's leading Event Organizer

Back

Qin Huang

MD,PhD, Harvard Medical School/VA Boston, USA

Title: Current Understanding of Gastric Cardiac Carcinoma

Biography

Biography: Qin Huang

Abstract

Gastric cardiac carcinoma (GCC) arises in the cardiac mucosa located primarily in the proximal stomach within 3 cm below the gastroesophageal junction. The 7th edition of the American Joint Committee on Cancer (AJCC7) staging scheme classified this carcinoma as esophageal adenocarcinoma (EAC), which has been shown to be inadequate by recent research results. The data from high-quality research papers show a rising incidence of GCC in East Asian countries, but a decreasing trend in the West, and a plateaued low level in the United States. The studies from China and Japan suggest a slow progression natural history in GCC, especially at the early stage. While risk factors and tumorigenesis mechanisms for GCC remain elusive, histopathologic investigations demonstrate a wide histopathologic spectrum with a predominance of the Lauren intestinal type carcinoma and rare cancer types such as carcinosarcoma, adenosquamous and neuroendocrine carcinomas, and carcinoma with lymphoid stroma, in contrast to a low frequency for poorly cohesive carcinoma including signet-ring cell carcinoma. Because of heterogeneous post-resection patient survival characteristics, patient survival cannot be adequately stratified and staged by the AJCC7 staging rules on the EAC. The recent results on genomic investigations of gastric and esophageal cancers reveal a unique genetic profile in GCC with a predominance of a gastric chromosomal instability type, which is the same as EAC, indicating the same molecular type for both EAC and GCC. The most recent multicenter study in 15 countries with 25411 radical gastrectomies exhibited a clear stratification of GCC patient prognosis with the staging rule for gastric cancer. Thus, the updated AJCC 8th manual has reversed the staging role in AJCC7 and re-classified GCC as gastric cancer. These outstanding progresses have significantly advanced our understanding of GCC and direct future investigations to a new direction with the goal to cure this potentially fatal cancer